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Document type:
Journal Article; Article 
Author(s):
Dietrich, Michael; Koska, Valeria; Hecker, Christina; Göttle, Peter; Hilla, Alexander M; Heskamp, Annemarie; Lepka, Klaudia; Issberner, Andrea; Hallenberger, Angelika; Baksmeier, Christine; Steckel, Julia; Balk, Lisanne; Knier, Benjamin; Korn, Thomas; Havla, Joachim; Martínez-Lapiscina, Elena H; Solà-Valls, Nuria; Manogaran, Praveena; Olbert, Elisabeth D; Schippling, Sven; Cruz-Herranz, Andrés; Yiu, Hao; Button, Julia; Caldito, Natalia Gonzalez; von Gall, Charlotte; Mausberg, Anne K; Stettner, M...    »
 
Title:
Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis. 
Abstract:
Chronic disability in multiple sclerosis is linked to neuroaxonal degeneration. 4-aminopyridine (4-AP) is used and licensed as a symptomatic treatment to ameliorate ambulatory disability in multiple sclerosis. The presumed mode of action is via blockade of axonal voltage gated potassium channels, thereby enhancing conduction in demyelinated axons. In this study, we provide evidence that in addition to those symptomatic effects, 4-AP can prevent neuroaxonal loss in the CNS. Using in vivo optical...    »
 
Journal title abbreviation:
Brain 
Year:
2020 
Journal volume:
143 
Journal issue:
Pages contribution:
1127-1142 
Fulltext / DOI:
Print-ISSN:
0006-8950 
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik