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Document type:
Article; Journal Article 
Author(s):
Müller, Thomas R; Schuler, Corinna; Hammel, Monika; Köhler, Amelie; Jutz, Sabrina; Leitner, Judith; Schober, Kilian; Busch, Dirk H; Steinberger, Peter 
Title:
A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology. 
Abstract:
Objective: Transgenic re-expression enables unbiased investigation of T-cell receptor (TCR)-intrinsic characteristics detached from its original cellular context. Recent advancements in TCR repertoire sequencing and development of protocols for direct cloning of full TCRαβ constructs now facilitate large-scale transgenic TCR re-expression. Together, this offers unprecedented opportunities for the screening of TCRs for basic research as well as clinical use. However, the functional characterisati...    »
 
Journal title abbreviation:
Clin Transl Immunology 
Year:
2020 
Journal volume:
Journal issue:
11 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene