User: Guest  Login
Document type:
Article; Journal Article 
Müller, Thomas R; Schuler, Corinna; Hammel, Monika; Köhler, Amelie; Jutz, Sabrina; Leitner, Judith; Schober, Kilian; Busch, Dirk H; Steinberger, Peter 
A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology. 
Objective: Transgenic re-expression enables unbiased investigation of T-cell receptor (TCR)-intrinsic characteristics detached from its original cellular context. Recent advancements in TCR repertoire sequencing and development of protocols for direct cloning of full TCRαβ constructs now facilitate large-scale transgenic TCR re-expression. Together, this offers unprecedented opportunities for the screening of TCRs for basic research as well as clinical use. However, the functional characterisati...    »
Journal title abbreviation:
Clin Transl Immunology 
Journal volume:
Journal issue:
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene