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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Wuerth, Jennifer Deborah; Habjan, Matthias; Kainulainen, Markus; Berisha, Besim; Bertheloot, Damien; Superti-Furga, Giulio; Pichlmair, Andreas; Weber, Friedemann 
Title:
eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition. 
Abstract:
RNA-activated protein kinase (PKR) is a major innate immune factor that senses viral double-stranded RNA (dsRNA) and phosphorylates eukaryotic initiation factor (eIF) 2α. Phosphorylation of the α subunit converts the eIF2αβγ complex into a stoichiometric inhibitor of eukaryotic initiation factor eIF2B, thus halting mRNA translation. To escape this protein synthesis shutoff, viruses have evolved countermechanisms such as dsRNA sequestration, eIF-independent translation by an internal ribosome bin...    »
 
Journal title abbreviation:
MBio 
Year:
2020 
Journal volume:
11 
Journal issue:
Fulltext / DOI:
Print-ISSN:
2150-7511 
TUM Institution:
Institut für Virologie