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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Liu, Peter Jianrui; Harris, James M; Marchi, Emanuele; D'Arienzo, Valentina; Michler, Thomas; Wing, Peter A C; Magri, Andrea; Ortega-Prieto, Ana Maria; van de Klundert, Maarten; Wettengel, Jochen; Durantel, David; Dorner, Marcus; Klenerman, Paul; Protzer, Ulrike; Giotis, Efstathios S; McKeating, Jane A 
Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models. 
Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) worldwide. The prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) pathway is a key mammalian oxygen sensing pathway and is frequently perturbed by pathological states including infection and inflammation. We discovered a significant upregulation of hypoxia regulated gene transcripts in patients with chronic hepatitis B (CHB) in the absence of liver cirrhosis. We used state-of-the-art in vitro and in vivo H...    »
Journal title abbreviation:
Sci Rep 
Journal volume:
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TUM Institution:
Institut für Virologie