User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Liu, Peter Jianrui; Harris, James M; Marchi, Emanuele; D'Arienzo, Valentina; Michler, Thomas; Wing, Peter A C; Magri, Andrea; Ortega-Prieto, Ana Maria; van de Klundert, Maarten; Wettengel, Jochen; Durantel, David; Dorner, Marcus; Klenerman, Paul; Protzer, Ulrike; Giotis, Efstathios S; McKeating, Jane A 
Title:
Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models. 
Abstract:
Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) worldwide. The prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) pathway is a key mammalian oxygen sensing pathway and is frequently perturbed by pathological states including infection and inflammation. We discovered a significant upregulation of hypoxia regulated gene transcripts in patients with chronic hepatitis B (CHB) in the absence of liver cirrhosis. We used state-of-the-art in vitro and in vivo H...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2020 
Journal volume:
10 
Journal issue:
Print-ISSN:
2045-2322 
TUM Institution:
Institut für Virologie