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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Varga, Julia; Nicolas, Adele; Petrocelli, Valentina; Pesic, Marina; Mahmoud, Abdelrahman; Michels, Birgitta E; Etlioglu, Emre; Yepes, Diego; Häupl, Björn; Ziegler, Paul K; Bankov, Katrin; Wild, Peter J; Wanninger, Stefan; Medyouf, Hind; Farin, Henner F; Tejpar, Sabine; Oellerich, Thomas; Ruland, Jürgen; Siebel, Christian W; Greten, Florian R 
Title:
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer. 
Abstract:
Recently, a transcriptome-based consensus molecular subtype (CMS) classification of colorectal cancer (CRC) has been established, which may ultimately help to individualize CRC therapy. However, the lack of animal models that faithfully recapitulate the different molecular subtypes impedes adequate preclinical testing of stratified therapeutic concepts. Here, we demonstrate that constitutive AKT activation in intestinal epithelial cells markedly enhances tumor invasion and metastasis in Trp53ΔIE...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2020 
Journal volume:
217 
Journal issue:
10 
Fulltext / DOI:
Print-ISSN:
0022-1007 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie