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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Lorenz, Georg; Moog, Philipp; Bachmann, Quirin; La Rosée, Paul; Schneider, Heike; Schlegl, Michaela; Spinner, Christoph; Heemann, Uwe; Schmid, Roland M; Algül, Hana; Lahmer, Tobias; Huber, Wolfgang; Schmaderer, Christoph 
Title:
Title: Cytokine release syndrome is not usually caused by secondary hemophagocytic lymphohistiocytosis in a cohort of 19 critically ill COVID-19 patients. 
Abstract:
Severe COVID-19 associated respiratory failure, poses the one challenge of our days. Assessment and treatment of COVID-19 associated hyperinflammation may be key to improve outcomes. It was speculated that in subgroups of patients secondary hemophagocytic lymphohistiocytosis (sHLH) or cytokine release syndrome (CRS) with features of macrophage activation syndrome might drive severe disease trajectories. If confirmed, profound immunosuppressive therapy would be a rationale treatment approach. Ove...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2020 
Journal volume:
10 
Journal issue:
Print-ISSN:
2045-2322 
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann); II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Klinische Chemie und Pathobiochemie; Lehrstuhl für Tumormetabolismus (Prof. Algül)