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Document type:
Journal Article 
Author(s):
Hopfner, Franziska; Mueller, Stefanie H; Szymczak, Silke; Junge, Olaf; Tittmann, Lukas; May, Sandra; Lohmann, Katja; Grallert, Harald; Lieb, Wolfgang; Strauch, Konstantin; Müller-Nurasyid, Martina; Berger, Klaus; Schormair, Barbara; Winkelmann, Juliane; Mollenhauer, Brit; Trenkwalder, Claudia; Maetzler, Walter; Berg, Daniela; Kasten, Meike; Klein, Christine; Höglinger, Günter U; Gasser, Thomas; Deuschl, Günther; Franke, André; Krawczak, Michael; Dempfle, Astrid; Kuhlenbäumer, Gregor 
Title:
Rare Variants in Specific Lysosomal Genes Are Associated With Parkinson's Disease. 
Abstract:
OBJECTIVE: Impaired lysosomal degradation of α-synuclein and other cellular constituents may play an important role in Parkinson's disease (PD). Rare genetic variants in the glucocerebrosidase (GBA) gene were consistently associated with PD. Here we examine the association between rare variants in lysosomal candidate genes and PD. METHODS: We investigated the association between PD and rare genetic variants in 23 lysosomal candidate genes in 4096 patients with PD and an equal number of controls...    »
 
Journal title abbreviation:
Mov Disord 
Year:
2020 
Journal volume:
35 
Journal issue:
Pages contribution:
1245-1248 
Fulltext / DOI:
Print-ISSN:
0885-3185 
TUM Institution:
1452; 658; Institut für Humangenetik; Lehrstuhl für Neurogenetik (Prof. Winkelmann)