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Document type:
Zeitschriftenaufsatz 
Author(s):
Marczynski, Matthias; Balzer, Bizan N.; Jiang, Kun; Lutz, Theresa M.; Crouzier, Thomas; Lieleg, Oliver 
Title:
Charged glycan residues critically contribute to the adsorption and lubricity of mucins 
Abstract:
In the human body, mucin glycoproteins efficiently reduce friction between tissues and thereby protect the mucosa from mechanical damage. Mucin lubricity is closely related to their molecular structure: it has been demonstrated previously that the hydrophobic termini of mucins critically contribute to their lubricity. If and how intrinsic sources of negative charge in mucins, e.g., sulfated glycans and sialic acid residues, are relevant for the tribological behavior of mucin solutions has, howev...    »
 
Keywords:
Adsorption, AFM, DNA, Lubricity, Mucin, QCM-D, Sialic acid, Sulfate, Tribology 
Dewey Decimal Classification:
500 Naturwissenschaften 
Journal title:
Colloids and Surfaces B: Biointerfaces 
Year:
2020 
Journal volume:
187 
Pages contribution:
110614 
Covered by:
Scopus 
Reviewed:
ja 
Language:
en 
Publisher:
Elsevier BV 
E-ISSN:
0927-7765 
Date of publication:
01.03.2020 
TUM Institution:
Fachgebiet für Biomechanik