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Original title:
NMR structural studies of full-length Bcl-xL in nanodiscs
Translated title:
NMR-struktrulle Studien von volllängen Bcl-xL in nanodiscs
Author:
Raltchev, Kolio Pavlinov
Year:
2020
Document type:
Dissertation
Faculty/School:
Fakultät für Chemie
Advisor:
Hagn, Franz (Prof. Dr.)
Referee:
Hagn, Franz (Prof. Dr.); Reif, Bernd (Prof. Dr.)
Language:
en
Subject group:
CHE Chemie
Keywords:
Bcl-xL, Nanodiscs, tail-anchored proteins, NMR
Translated keywords:
Bcl-xL, Nanodiscs, tail-anchored proteins, NMR
TUM classification:
CHE 887d
Abstract:
The focus of this study is the development of new methods for the production of the full-length tail-anchored membrane proteins, specifically the B-cell lymphoma-extralarge (Bcl-xL), a member of the Bcl-2 family,as well as their structural investigation in phospholipid nanodiscs. The developed methods are applied to studying the membrane-bound and inserted Bcl-xL and to probe its membrane location and possible membrane insertion processes in a native-like environment.
Translated abstract:
Der Fokus dieser Arbeit ist die Entwicklung neuer Methoden zur Produktion von tail-anchored Proteinen, insbesondere von Bcl-xL (B-cell lymphoma extra large), sowie deren strukturelle Untersuchung in Phospholipid Nanodiscs. Die entwickelten Methoden werden angewendet, um die membrangebundene und verankerte Form von Bcl-xL zu untersuchen und um deren Membranlokalisation beziehungsweise mögliche Membraninsertionsprozesse in einer möglichst nativen Umgebung zu erforschen.
WWW:
https://mediatum.ub.tum.de/?id=1524383
Date of submission:
26.11.2019
Oral examination:
10.02.2020
File size:
9252596 bytes
Pages:
208
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20200210-1524383-1-2
Last change:
09.06.2020
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