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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ludwig, Beatrice Stefanie; Tomassi, Stefano; Di Maro, Salvatore; Di Leva, Francesco Saverio; Benge, Anke; Reichart, Florian; Nieberler, Markus; Kühn, Fritz E; Kessler, Horst; Marinelli, Luciana; Reuning, Ute; Kossatz, Susanne
Titel:
The organometallic ferrocene exhibits amplified anti-tumor activity by targeted delivery via highly selective ligands to αvβ3, αvβ6, or α5β1 integrins.
Abstract:
High levels of reactive oxygen species (ROS) in tumors have been shown to exert anti-tumor activity, leading to the concept of ROS induction as therapeutic strategy. The organometallic compound ferrocene (Fc) generates ROS through a reversible one-electron oxidation. Incorporation of Fc into a tumor-targeting, bioactive molecule can enhance its therapeutic activity and enable tumor specific delivery. Therefore, we conjugated Fc to five synthetic, Arg-Gly-Asp (RGD)-based integrin binding ligands...     »
Zeitschriftentitel:
Biomaterials
Jahr:
2021
Band / Volume:
271
Volltext / DOI:
doi:10.1016/j.biomaterials.2021.120754
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33756215
Print-ISSN:
0142-9612
TUM Einrichtung:
Frauenklinik und Poliklinik; Klinik und Poliklinik für Nuklearmedizin
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