Salvage Surgery in Patients with Local Recurrence After Radical Prostatectomy.

Knipper, Sophie; Ascalone, Luigi; Ziegler, Benjamin; Hohenhorst, Jan L; Simon, Ricarda; Berliner, Christoph; van Leeuwen, Fijs W B; van der Poel, Henk; Giesel, Frederik; Graefen, Markus; Eiber, Matthias; Heck, Matthias M; Horn, Thomas; Maurer, Tobias

doi:10.1016/j.eururo.2020.11.012

2021

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Dokumenttyp:: Journal Article
Autor(en):: Knipper, Sophie; Ascalone, Luigi; Ziegler, Benjamin; Hohenhorst, Jan L; Simon, Ricarda; Berliner, Christoph; van Leeuwen, Fijs W B; van der Poel, Henk; Giesel, Frederik; Graefen, Markus; Eiber, Matthias; Heck, Matthias M; Horn, Thomas; Maurer, Tobias
Titel:: Salvage Surgery in Patients with Local Recurrence After Radical Prostatectomy.
Abstract:: BACKGROUND: Since the introduction of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging, isolated local recurrence after radical prostatectomy (RP) can be delineated accurately. OBJECTIVE: To describe and evaluate surgical technique, biochemical response, and therapy-free survival (TFS) after salvage surgery in patients with local recurrence in the seminal vesicle bed. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively assessed 40 patients treated with open salvage surgery in two centres (11/2014-02/2020). All patients presented with biochemical recurrence (BCR) after RP with a singular local recurrence at PSMA PET imaging. Thirty-three (82.5%) patients received previous salvage radiation therapy. SURGICAL PROCEDURE: Open salvage surgery with PSMA radioguidance. MEASUREMENTS: Prostate-specific antigen (PSA) nadir and percentage of patients with complete biochemical response (cBR) without further treatment (PSA < 0.2 ng/ml) after 6-16 wk were assessed. BCR-free survival and TFS were calculated using Kaplan-Meier estimates. Clavien-Dindo complications were evaluated. RESULTS AND LIMITATIONS: Prior to salvage surgery, median PSA was 0.9 ng/ml (interquartile range [IQR]: 0.5-1.7 ng/ml). Postoperatively, median PSA nadir was 0.1 ng/ml (IQR: 0-0.4 ng/ml). In 31 (77.5%) patients, cBR was observed. During the median follow-up of 24.4 months, 22 (55.0%) patients experienced BCR and 12 (30.0%) received further therapy. At 1 yr of follow-up, BCR-free survival rate was 62.2% and TFS rate was 88.3%. Three (7.5%) Clavien-Dindo grade III complications were observed. The main limitations are the retrospective design, short follow-up, and lack of a control group. CONCLUSIONS: Salvage surgery of local recurrence within the seminal vesicle bed is feasible. It may present an opportunity in selected, locally recurrent patients to prolong BCR-free survival and increase TFS. Further studies are needed to confirm our findings. PATIENT SUMMARY: We looked at the outcomes from prostate cancer patients with locally recurrent disease after radical prostatectomy and radiotherapy. We found that surgery in well-selected patients may be an opportunity to prolong treatment-free survival.
Zeitschriftentitel:: Eur Urol
Jahr:: 2021
Band / Volume:: 79
Heft / Issue:: 4
Seitenangaben Beitrag:: 537-544
Volltext / DOI:: doi:10.1016/j.eururo.2020.11.012
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/33317857
Print-ISSN:: 0302-2838
TUM Einrichtung:: Klinik und Poliklinik für Nuklearmedizin; Urologische Klinik und Poliklinik
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