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- Dokumenttyp:
- Journal Article
- Autor(en):
- Wurster, Thomas H; Landmesser, Ulf; Abdelwahed, Youssef S; Skurk, Carsten; Morguet, Andreas; Leistner, David M; Fröhlich, Georg; Haghikia, Arash; Engel, Leif-Christopher; Schuster, Andreas; Noutsias, Michel; Schulze, Daniel; Hamm, Bernd; Furth, Christian; Brenner, Winfried; Botnar, Rene M; Bigalke, Boris; Makowski, Marcus R
- Titel:
- Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization.
- Abstract:
- AIMS: 18F-sodium fluoride ([18F]fluoride) and gadobutrol are promising probes for positron emission tomography (PET) and magnetic resonance imaging (MRI) characterizing coronary artery disease (CAD) activity. Unlike [18F]fluoride-PET/computed tomography (CT), the potential of PET/MR using [18F]fluoride and gadobutrol simultaneously, has so far not been evaluated. This study assessed feasibility and diagnostic potential of [18F]fluoride and gadobutrol enhanced dual-probe PET/MR in patients with CAD. METHODS AND RESULTS: Twenty-one patients (age, 66.7 ± 6.7 years) with CAD scheduled for invasive coronary angiography (XCA) underwent simultaneous [18F]fluoride (mean activity/effective dose: 157.2 ± 29.7 MBq/3.77 ± 0.72 mSv) and gadobutrol enhanced PET/MR on an integrated PET/MRI (3 T) scanner. Optical coherence tomography (OCT) was used as reference. Target-to-background ratio (TBR, [18F]fluoride-PET) and contrast-to-noise ratio (CNR) values (MRI, gadobutrol) were calculated for each coronary segment. Previously suggested PET/CT-TBR thresholds for adverse coronary events were evaluated. High-risk plaques, i.e. calcified and non-calcified thin-cap fibroatheromas (TCFAs) were predominantly located in segments with a TBR >1.28 (P = 0.012). Plaques containing a lipid core on OCT, were more frequently detected in segments with a TBR >1.25 (P < 0.001). TBR values significantly correlated with maximum calcification thickness (P = 0.009), while fibrous cap thickness was significantly less in segments with a TBR >1.28 (P = 0.044). Above a TBR threshold of >1.28, CNR values significantly correlated with the presence of calcified TCFAs (P = 0.032). CONCLUSION: Simultaneous [18F]fluoride and gadobutrol dual-probe PET/MRI is feasible in clinical practice and may facilitate the identification of high-risk patients. The combination of coronary MR-derived CNR values post gadobutrol and [18F]fluoride based TBR values may improve identification of high-risk plaque features.
- Zeitschriftentitel:
- Eur Heart J Cardiovasc Imaging
- Jahr:
- 2022
- Band / Volume:
- 23
- Heft / Issue:
- 10
- Seitenangaben Beitrag:
- 1391-1398
- Volltext / DOI:
- doi:10.1093/ehjci/jeab276
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/35015852
- Print-ISSN:
- 2047-2404
- TUM Einrichtung:
- Institut für Diagnostische und Interventionelle Radiologie
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