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- Document type:
- Journal Article; Comment
- Author(s):
- Diakopoulos, Kalliope N; Algül, Hana
- Title:
- New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis.
- Abstract:
- Obesity and acute pancreatitis are both proinflammatory conditions. Importantly, obesity increases severity in acute pancreatitis by enhancing inflammation. In a recent issue of The Journal of Pathology, Pérez and Ruiz-Pérez et al connected obesity and pancreatitis for the first time, through the transcriptional regulator PPARγ coactivator 1α (PGC-1α). Obesity reduces pancreatic PGC-1α levels and potentiates not only oxidative but also IL-6-mediated inflammatory damage during acute pancreatitis by relieving the binding of PGC-1α to the NF-κB subunit p65. Blockade of the IL-6 receptor subunit gp130 ameliorated tissue injury, substantiating the importance of deregulated PGC-1α/p65/IL-6 signaling in obesity and acute pancreatitis. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
- Journal title abbreviation:
- J Pathol
- Year:
- 2019
- Journal volume:
- 248
- Journal issue:
- 1
- Pages contribution:
- 6-8
- Fulltext / DOI:
- doi:10.1002/path.5220
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/30570131
- Print-ISSN:
- 0022-3417
- TUM Institution:
- Lehrstuhl für Tumormetabolismus (Prof. Algül)
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