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Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Stark, Konstantin; Schubert, Irene; Joshi, Urjita; Kilani, Badr; Hoseinpour, Parandis; Thakur, Manovriti; Grünauer, Petra; Pfeiler, Susanne; Schmidergall, Tobias; Stockhausen, Sven; Bäumer, Markus; Chandraratne, Sue; von Brühl, Marie-Luise; Lorenz, Michael; Coletti, Raffaele; Reese, Sven; Laitinen, Iina; Wörmann, Sonja Maria; Algül, Hana; Bruns, Christiane J; Ware, Jerry; Mackman, Nigel; Engelmann, Bernd; Massberg, Steffen 
Title:
Distinct Pathogenesis of Pancreatic Cancer Microvesicle-Associated Venous Thrombosis Identifies New Antithrombotic Targets In Vivo. 
Abstract:
Cancer patients are at high risk of developing deep venous thrombosis (DVT) and venous thromboembolism, a leading cause of mortality in this population. However, it is largely unclear how malignant tumors drive the prothrombotic cascade culminating in DVT.Here, we addressed the pathophysiology of malignant DVT compared with nonmalignant DVT and focused on the role of tumor microvesicles as potential targets to prevent cancer-associated DVT. We show that microvesicles released by pancreatic adeno...    »
 
Journal title abbreviation:
Arterioscler Thromb Vasc Biol 
Year:
2018 
Journal volume:
38 
Journal issue:
Pages contribution:
772-786 
Print-ISSN:
1079-5642 
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)