New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis.

Dokumenttyp:: Journal Article; Comment
Autor(en):: Diakopoulos, Kalliope N; Algül, Hana
Titel:: New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis.
Abstract:: Obesity and acute pancreatitis are both proinflammatory conditions. Importantly, obesity increases severity in acute pancreatitis by enhancing inflammation. In a recent issue of The Journal of Pathology, Pérez and Ruiz-Pérez et al connected obesity and pancreatitis for the first time, through the transcriptional regulator PPARγ coactivator 1α (PGC-1α). Obesity reduces pancreatic PGC-1α levels and potentiates not only oxidative but also IL-6-mediated inflammatory damage during acute pancreatitis by relieving the binding of PGC-1α to the NF-κB subunit p65. Blockade of the IL-6 receptor subunit gp130 ameliorated tissue injury, substantiating the importance of deregulated PGC-1α/p65/IL-6 signaling in obesity and acute pancreatitis. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Zeitschriftentitel:: J Pathol
Jahr:: 2019
Band / Volume:: 248
Heft / Issue:: 1
Seitenangaben Beitrag:: 6-8
Volltext / DOI:: doi:10.1002/path.5220
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/30570131
Print-ISSN:: 0022-3417
TUM Einrichtung:: Lehrstuhl für Tumormetabolismus (Prof. Algül)
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