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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Andlauer, Till F M; Link, Jenny; Martin, Dorothea; Ryner, Malin; Hermanrud, Christina; Grummel, Verena; Auer, Michael; Hegen, Harald; Aly, Lilian; Gasperi, Christiane; Knier, Benjamin; Müller-Myhsok, Bertram; Jensen, Poul Erik Hyldgaard; Sellebjerg, Finn; Kockum, Ingrid; Olsson, Tomas; Pallardy, Marc; Spindeldreher, Sebastian; Deisenhammer, Florian; Fogdell-Hahn, Anna; Hemmer, Bernhard 
Title:
Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS. 
Abstract:
BACKGROUND: Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis patients treated with interferon β (IFNβ) develop ADA, for which a genetic predisposition exists. Here, we present a genome-wide association study on ADA and predict the occurrence of antibodies in multiple sclerosis patients treated with different interferon β preparations. METHODS: We analyzed a large sample of 2757 genotyped and...    »
 
Journal title abbreviation:
BMC Med 
Year:
2020 
Journal volume:
18 
Journal issue:
Print-ISSN:
1741-7015 
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik