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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Śledzińska, Anna; Vila de Mucha, Maria; Bergerhoff, Katharina; Hotblack, Alastair; Demane, Dafne Franz; Ghorani, Ehsan; Akarca, Ayse U; Marzolini, Maria A V; Solomon, Isabelle; Vargas, Frederick Arce; Pule, Martin; Ono, Masahiro; Seddon, Benedict; Kassiotis, George; Ariyan, Charlotte E; Korn, Thomas; Marafioti, Teresa; Lord, Graham M; Stauss, Hans; Jenner, Richard G; Peggs, Karl S; Quezada, Sergio A 
Title:
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells. 
Abstract:
In addition to helper and regulatory potential, CD4+ T cells also acquire cytotoxic activity marked by granzyme B (GzmB) expression and the ability to promote rejection of established tumors. Here, we examined the molecular and cellular mechanisms underpinning the differentiation of cytotoxic CD4+ T cells following immunotherapy. CD4+ transfer into lymphodepleted animals or regulatory T (Treg) cell depletion promoted GzmB expression by tumor-infiltrating CD4+, and this was prevented by interleuk...    »
 
Journal title abbreviation:
Immunity 
Year:
2020 
Journal volume:
52 
Journal issue:
Pages contribution:
151-166.e6 
Print-ISSN:
1074-7613 
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik