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Document type:
Journal Article 
Author(s):
Russo, Gianluca L; Sonsalla, Giovanna; Natarajan, Poornemaa; Breunig, Christopher T; Bulli, Giorgia; Merl-Pham, Juliane; Schmitt, Sabine; Giehrl-Schwab, Jessica; Giesert, Florian; Jastroch, Martin; Zischka, Hans; Wurst, Wolfgang; Stricker, Stefan H; Hauck, Stefanie M; Masserdotti, Giacomo; Götz, Magdalena 
Title:
CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion. 
Abstract:
Astrocyte-to-neuron conversion is a promising avenue for neuronal replacement therapy. Neurons are particularly dependent on mitochondrial function, but how well mitochondria adapt to the new fate is unknown. Here, we determined the comprehensive mitochondrial proteome of cortical astrocytes and neurons, identifying about 150 significantly enriched mitochondrial proteins for each cell type, including transporters, metabolic enzymes, and cell-type-specific antioxidants. Monitoring their transitio...    »
 
Journal title abbreviation:
Cell Stem Cell 
Year:
2021 
Journal volume:
28 
Journal issue:
Pages contribution:
524-534.e7 
Print-ISSN:
1934-5909 
TUM Institution:
Institut für Toxikologie und Umwelthygiene