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Document type:
Journal Article; Article 
Author(s):
Hernandez-Garzón, Edwin; Fernandez, Ana M; Perez-Alvarez, Alberto; Genis, Laura; Bascuñana, Pablo; Fernandez de la Rosa, Ruben; Delgado, Mercedes; Angel Pozo, Miguel; Moreno, Estefanía; McCormick, Peter J; Santi, Andrea; Trueba-Saiz, Angel; García-Cáceres, Cristina; Tschöp, Matthias H; Araque, Alfonso; Martin, Eduardo D; Torres Aleman, Ignacio 
Title:
The insulin-like growth factor I receptor regulates glucose transport by astrocytes. 
Abstract:
Previous findings indicate that reducing brain insulin-like growth factor I receptor (IGF-IR) activity promotes ample neuroprotection. We now examined a possible action of IGF-IR on brain glucose transport to explain its wide protective activity, as energy availability is crucial for healthy tissue function. Using (18) FGlucose PET we found that shRNA interference of IGF-IR in mouse somatosensory cortex significantly increased glucose uptake upon sensory stimulation. In vivo microscopy using ast...    »
 
Journal title abbreviation:
Glia 
Year:
2016 
Journal volume:
64 
Journal issue:
11 
Pages contribution:
1962-71 
Fulltext / DOI:
Print-ISSN:
0894-1491 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)