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Document type:
Journal Article 
Author(s):
von Gamm, Matthias; Schaub, Annalisa; Jones, Alisha N; Wolf, Christine; Behrens, Gesine; Lichti, Johannes; Essig, Katharina; Macht, Anna; Pircher, Joachim; Ehrlich, Andreas; Davari, Kathrin; Chauhan, Dhruv; Busch, Benjamin; Wurst, Wolfgang; Feederle, Regina; Feuchtinger, Annette; Tschöp, Matthias H; Friedel, Caroline C; Hauck, Stefanie M; Sattler, Michael; Geerlof, Arie; Hornung, Veit; Heissmeyer, Vigo; Schulz, Christian; Heikenwälder, Mathias; Glasmacher, Elke 
Title:
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. 
Abstract:
The RNase Regnase-1 is a master RNA regulator in macrophages and T cells that degrades cellular and viral RNA upon NF-κB signaling. The roles of its family members, however, remain largely unknown. Here, we analyzed Regnase-3-deficient mice, which develop hypertrophic lymph nodes. We used various mice with immune cell-specific deletions of Regnase-3 to demonstrate that Regnase-3 acts specifically within myeloid cells. Regnase-3 deficiency systemically increased IFN signaling, which increased the...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2019 
Journal volume:
216 
Journal issue:
Pages contribution:
1700-1723 
Fulltext / DOI:
Print-ISSN:
0022-1007 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)