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Document type:
Journal Article 
Author(s):
Harrison, Luke; Schriever, Sonja C; Feuchtinger, Annette; Kyriakou, Eleni; Baumann, Peter; Pfuhlmann, Katrin; Messias, Ana C; Walch, Axel; Tschöp, Matthias H; Pfluger, Paul T 
Title:
Fluorescent blood-brain barrier tracing shows intact leptin transport in obese mice. 
Abstract:
BACKGROUND/OBJECTIVES: Individuals carrying loss-of-function gene mutations for the adipocyte hormone leptin are morbidly obese, but respond favorably to replacement therapy. Recombinant leptin is however largely ineffective for the vast majority of obese individuals due to leptin resistance. One theory underlying leptin resistance is impaired leptin transport across the blood-brain-barrier (BBB). Here, we aim to gain new insights into the mechanisms of leptin BBB transport, and its role in lept...    »
 
Journal title abbreviation:
Int J Obes (Lond) 
Year:
2019 
Journal volume:
43 
Journal issue:
Pages contribution:
1305-1318 
Print-ISSN:
0307-0565 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)