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Document type:
Journal Article 
Author(s):
Schriever, Sonja C; Kabra, Dhiraj G; Pfuhlmann, Katrin; Baumann, Peter; Baumgart, Emily V; Nagler, Joachim; Seebacher, Fabian; Harrison, Luke; Irmler, Martin; Kullmann, Stephanie; Corrêa-da-Silva, Felipe; Giesert, Florian; Jain, Ruchi; Schug, Hannah; Castel, Julien; Martinez, Sarah; Wu, Moya; Häring, Hans-Ulrich; de Angelis, Martin Hrabe; Beckers, Johannes; Müller, Timo D; Stemmer, Kerstin; Wurst, Wolfgang; Rozman, Jan; Nogueiras, Ruben; De Angelis, Meri; Molkentin, Jeffery D; Krahmer, Natalie;...    »
 
Title:
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity. 
Abstract:
Recent genome-wide association studies (GWAS) identified DUSP8, encoding a dual-specificity phosphatase targeting mitogen-activated protein kinases, as a type 2 diabetes (T2D) risk gene. Here, we reveal that Dusp8 is a gatekeeper in the hypothalamic control of glucose homeostasis in mice and humans. Male, but not female, Dusp8 loss-of-function mice, either with global or corticotropin-releasing hormone neuron-specific deletion, had impaired systemic glucose tolerance and insulin sensitivity when...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2020 
Journal volume:
130 
Journal issue:
11 
Pages contribution:
6093-6108 
Fulltext / DOI:
Print-ISSN:
0021-9738 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)