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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review 
Author(s):
Metzger, J; Luppa, PB; Good, DM; Mischak, H 
Title:
Adapting mass spectrometry-based platforms for clinical proteomics applications: The capillary electrophoresis coupled mass spectrometry paradigm. 
Abstract:
Single biomarker detection is common in clinical laboratories due to the currently available method spectrum. For various diseases, however, no specific single biomarker could be identified. A strategy to overcome this diagnostic void is to shift from single analyte detection to multiplexed biomarker profiling. Mass spectrometric methods were employed for biomarker discovery in body fluids. The enormous complexity of biofluidic proteome compartments implies upstream fractionation. For this reaso...    »
 
Journal title abbreviation:
Crit Rev Clin Lab Sci 
Year:
2009 
Journal volume:
46 
Journal issue:
Pages contribution:
129-52 
Language:
eng 
Print-ISSN:
1040-8363 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie