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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Chen, X; Kovalchuk, Y; Adelsberger, H; Henning, HA; Sausbier, M; Wietzorrek, G; Ruth, P; Yarom, Y; Konnerth, A 
Title:
Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels. 
Abstract:
The large-conductance voltage- and calcium-activated potassium (BK) channels are ubiquitously expressed in the brain and play an important role in the regulation of neuronal excitation. Previous work has shown that the total deletion of these channels causes an impaired motor behavior, consistent with a cerebellar dysfunction. Cellular analyses showed that a decrease in spike firing rate occurred in at least two types of cerebellar neurons, namely in Purkinje neurons (PNs) and in Golgi cells. To...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2010 
Journal volume:
107 
Journal issue:
27 
Pages contribution:
12323-8 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Neurowissenschaften