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Dokumenttyp:
journal article 
Autor(en):
Stroh, A; Tsai, HC; Ping Wang, L; Zhang, F; Kressel, J; Aravanis, A; Santhanam, N; Deisseroth, K; Konnerth, A; Schneider, MB 
Titel:
Tracking stem cell differentiation in the setting of automated optogenetic stimulation. 
Abstract:
Membrane depolarization has been shown to play an important role in the neural differentiation of stem cells as well as in the survival and function of mature neurons. Here we introduce a microbial opsin into embryonic stem cells and develop optogenetic technology for stem cell engineering applications, with an automated system for noninvasive modulation of embryonic stem cell differentiation employing fast optogenetic control of ion flux. Mouse embryonic stem cells (ESCs) were stably transduced...    »
 
Zeitschriftentitel:
Stem Cells 
Jahr:
2010 
Sprache:
eng 
Print-ISSN:
1066-5099 
TUM Einrichtung:
Abteilung für Neuroradiologie ; Institut für Neurowissenschaften