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Document type:
Journal Article 
Author(s):
von Freyend, MJ; Untergasser, A; Arzberger, S; Oberwinkler, H; Drebber, U; Schirmacher, P; Protzer, U 
Title:
Sequential control of hepatitis B virus in a mouse model of acute, self-resolving hepatitis B. 
Abstract:
The determinants of an immune response to the human hepatitis B virus (HBV) are poorly understood. As studies in man and chimpanzees are limited, we aimed at developing a model of self-limiting hepatitis B in mice that helps to dissect the control of HBV by humoral and cellular immune responses. Adenoviral vectors containing 1.3-fold HBV genomes allowed an efficient and reproducible transfer of HBV genomes into mouse livers and initiated HBV replication in mice. HBV transcripts were detected in...    »
 
Journal title abbreviation:
J Viral Hepat 
Year:
2011 
Journal volume:
18 
Journal issue:
Pages contribution:
216-26 
Language:
eng 
Print-ISSN:
1352-0504 
TUM Institution:
Institut für Virologie