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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Hoegen, T; Tremel, N; Klein, M; Angele, B; Wagner, H; Kirschning, C; Pfister, HW; Fontana, A; Hammerschmidt, S; Koedel, U 
Title:
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release. 
Abstract:
Streptococcus pneumoniae meningitis causes brain damage through inflammation-related pathways whose identity and mechanisms of action are yet unclear. We previously identified caspase-1, which activates precursor IL-1 type cytokines, as a central mediator of inflammation in pneumococcal meningitis. In this study, we demonstrate that lack of the inflammasome components ASC or NLRP3 that are centrally involved in caspase-1 activation decreases scores of clinical and histological disease severity a...    »
 
Journal title abbreviation:
J Immunol 
Year:
2011 
Journal volume:
187 
Journal issue:
10 
Pages contribution:
5440-51 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene