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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't 
Autor(en):
Kolk, A; Haczek, C; Koch, C; Vogt, S; Kullmer, M; Pautke, C; Deppe, H; Plank, C 
Titel:
A strategy to establish a gene-activated matrix on titanium using gene vectors protected in a polylactide coating. 
Abstract:
Bioactive implants are promising tools in regenerative medicine. Here we describe a versatile procedure for preparing a gene-activated matrix on titanium. Lyophilized copolymer-protected gene vectors (COPROGs) suspended in poly(d,l-lactide) (PDLLA) solutions in ethyl acetate were used to varnish solid surfaces. The gene-activated PDLLA surfaces were first established on polypropylene 96-well plates. Vector release from these surfaces in aqueous buffer, cell viability and gene transfer efficiency...    »
 
Zeitschriftentitel:
Biomaterials 
Jahr:
2011 
Band / Volume:
32 
Heft / Issue:
28 
Seitenangaben Beitrag:
6850-9 
Sprache:
eng 
Print-ISSN:
0142-9612 
TUM Einrichtung:
Fachgebiet Sportorthopädie (Prof. Imhoff); Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie