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Dokumenttyp:
Journal Article 
Autor(en):
Cui, H; Grosso, S; Schelter, F; Mari, B; Kruger, A 
Titel:
On the Pro-Metastatic Stress Response to Cancer Therapies: Evidence for a Positive Co-Operation between TIMP-1, HIF-1?, and miR-210. 
Abstract:
In contrast to expectations in the past that tumor starvation or unselective inhibition of proteolytic activity would cure cancer, there is accumulating evidence that microenvironmental stress, such as hypoxia or broad-spectrum inhibition of metalloproteinases can promote metastasis. In fact, malignant tumor cells, due to their genetic and epigenetic instability, are predisposed to react to stress by adaptation and, if the stress persists, by escape and formation of metastasis. Recent recognitio...    »
 
Zeitschriftentitel:
Front Pharmacol 
Jahr:
2012 
Band / Volume:
Seitenangaben Beitrag:
134 
Sprache:
eng 
Volltext / DOI:
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung