Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes.

Grismayer, B; Sato, S; Kopitz, C; Ries, C; Soelch, S; Schmitt, M; Baretton, G; Kruger, A; Luther, T; Kotzsch, M; Magdolen, V

doi:10.1515/hsz-2012-0206

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Document type:: Journal Article
Author(s):: Grismayer, B; Sato, S; Kopitz, C; Ries, C; Soelch, S; Schmitt, M; Baretton, G; Kruger, A; Luther, T; Kotzsch, M; Magdolen, V
Title:: Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes.
Abstract:: mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes. In the present study, individual breast cancer cell clones displaying low vs. high uPAR-del4/5 expression were analyzed demonstrating that uPAR-del4/5 leads to reduced cell adhesion and invasion in a dose-dependent manner. Additionally, matrix metalloproteinase-9 (MMP-9) was found to be strongly upregulated in uPAR-del4/5 overexpressing compared to vector control cells. uPAR-del4/5 may thus play an important role in the regulation of the extracellular proteolytic network and, by this, influence the metastatic potential of breast cancer cells. «
mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes. In the present study, individual breast cancer cell clones displaying low vs. high uPAR-del4/5 expression were analyzed demonstrating that uPAR-del4/5 leads to reduced cell adhesion and invasion in a dose-dependent manner. Additionally, matrix metalloproteinase-9 (MMP-9) was found to be strongly upregula... »
Journal title abbreviation:: Biol Chem
Year:: 2012
Journal volume:: 393
Journal issue:: 12
Pages contribution:: 1449-55
Language:: eng
Fulltext / DOI:: doi:10.1515/hsz-2012-0206
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/23096560
Print-ISSN:: 1431-6730
TUM Institution:: Frauenklinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung
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