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Document type:
Journal Article 
Author(s):
Schäfer, H; Dieckmann, C; Korniienko, O; Moldenhauer, G; Kiefel, H; Salnikov, A; Kruger, A; Altevogt, P; Sebens, S 
Title:
Combined treatment of L1CAM antibodies and cytostatic drugs improve the therapeutic response of pancreatic and ovarian carcinoma. 
Abstract:
The adhesion molecule L1CAM (CD171) accounts for enhanced motility, invasiveness and chemoresistance of tumor cells and represents a novel marker for various tumor entities including pancreatic and ovarian carcinoma. Recently, we showed that L1CAM inhibition increases the apoptotic response of tumor cells towards cytostatic drugs pointing to the potential of L1CAM to serve as a chemosensitizer in anti-cancer therapy. Thus, the present study evaluated the therapeutic potential of combined treatme...    »
 
Journal title abbreviation:
Cancer Lett 
Year:
2012 
Journal volume:
319 
Journal issue:
Pages contribution:
66-82 
Language:
eng 
Print-ISSN:
0304-3835 
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung