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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Kötzler, Miriam P; Blank, Simon; Bantleon, Frank I; Wienke, Martin; Spillner, Edzard; Meyer, Bernd 
Title:
Donor assists acceptor binding and catalysis of human ?1,6-fucosyltransferase. 
Abstract:
?1,6-Core-fucosyltransferase (FUT8) is a vital enzyme in mammalian physiological and pathophysiological processes such as tumorigenesis and progress of, among others, non-small cell lung cancer and colon carcinoma. It was also shown that therapeutic antibodies have a dramatically higher efficacy if the ?1,6-fucosyl residue is absent. However, specific and potent inhibitors for FUT8 and related enzymes are lacking. Hence, it is crucial to elucidate the structural basis of acceptor binding and the...    »
 
Journal title abbreviation:
ACS Chem Biol 
Year:
2013 
Journal volume:
Journal issue:
Pages contribution:
1830-40 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1554-8929 
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)