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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media; Article 
Author(s):
Mensch, Sigrid; Baraban, Marion; Almeida, Rafael; Czopka, Tim; Ausborn, Jessica; El Manira, Abdeljabbar; Lyons, David A 
Title:
Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. 
Abstract:
The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulat...    »
 
Journal title abbreviation:
Nat Neurosci 
Year:
2015 
Journal volume:
18 
Journal issue:
Pages contribution:
628-30 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1097-6256 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)