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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Carambia, Antonella; Freund, Barbara; Schwinge, Dorothee; Bruns, Oliver T; Salmen, Sunhild C; Ittrich, Harald; Reimer, Rudolph; Heine, Markus; Huber, Samuel; Waurisch, Christian; Eychmüller, Alexander; Wraith, David C; Korn, Thomas; Nielsen, Peter; Weller, Horst; Schramm, Christoph; Lüth, Stefan; Lohse, Ansgar W; Heeren, Joerg; Herkel, Johannes 
Title:
Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice. 
Abstract:
It is well-known that the liver can induce immune tolerance, yet this knowledge could, thus far, not be translated into effective treatments for autoimmune diseases. We have previously shown that liver sinusoidal endothelial cells (LSECs) could substantially contribute to hepatic tolerance through their ability to induce CD4+ Foxp3+ regulatory T cells (Tregs). Here, we explored whether the Treg-inducing potential of LSECs could be harnessed for the treatment of autoimmune disease.We engineered a...    »
 
Journal title abbreviation:
J Hepatol 
Year:
2015 
Journal volume:
62 
Journal issue:
Pages contribution:
1349-56 
Language:
eng 
Print-ISSN:
0168-8278 
TUM Institution:
Molekulare Immunologie (Prof. Knolle)