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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Knier, Benjamin; Rothhammer, Veit; Heink, Sylvia; Puk, Oliver; Graw, Jochen; Hemmer, Bernhard; Korn, Thomas 
Title:
Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis. 
Abstract:
Optic neuritis is a common inflammatory manifestation of multiple sclerosis (MS). In experimental autoimmune encephalomyelitis (EAE), the optic nerve is affected as well. Here, we investigated whether autoimmune inflammation in the optic nerve is distinct from inflammation in other parts of the central nervous system (CNS). In our study, inflammatory infiltrates in the optic nerve and the brain were characterized by a high fraction of Ly6G(+) granulocytes whereas in the spinal cord, macrophage i...    »
 
Journal title abbreviation:
J Autoimmun 
Year:
2015 
Journal volume:
56 
Pages contribution:
34-44 
Language:
eng 
Print-ISSN:
0896-8411 
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik