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Document type:
Journal Article 
Author(s):
Kocot, Carmen; Schindler, Aline R; Le Blanc, Alexander; Schmalenberg, Michael; Miesbach, Wolfgang; Spannagl, Michael; Luppa, Peter B 
Title:
Biomimetic biosensor to distinguish between inhibitory and non-inhibitory factor VIII antibodies. 
Abstract:
Patients with hereditary or acquired haemophilia A may develop inhibitory factor VIII (FVIII) antibodies. These disrupt FVIII activity predominantly by preventing the formation of the tenase complex, leading to a serious bleeding disorder. Antibodies without inhibiting activity, however, can also be found when screening patients with haemophilia A under FVIII supplementation. Therefore, the detection of only these allo- or autoantibodies from plasma is not sufficient. Rather, the characterizatio...    »
 
Journal title abbreviation:
Anal Bioanal Chem 
Year:
2015 
Journal volume:
407 
Journal issue:
19 
Pages contribution:
5685-93 
Language:
eng 
Print-ISSN:
1618-2642 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie