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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Tang, Man-Hung Eric; Dahlgren, Malin; Brueffer, Christian; Tjitrowirjo, Tamara; Winter, Christof; Chen, Yilun; Olsson, Eleonor; Wang, Kun; Törngren, Therese; Sjöström, Martin; Grabau, Dorthe; Bendahl, Pär-Ola; Rydén, Lisa; Niméus, Emma; Saal, Lao H; Borg, Ake; Gruvberger-Saal, Sofia K 
Title:
Remarkable similarities of chromosomal rearrangements between primary human breast cancers and matched distant metastases as revealed by whole-genome sequencing. 
Abstract:
To better understand and characterize chromosomal structural variation during breast cancer progression, we enumerated chromosomal rearrangements for 11 patients by performing low-coverage whole-genome sequencing of 11 primary breast tumors and their 13 matched distant metastases. The tumor genomes harbored a median of 85 (range 18-404) rearrangements per tumor, with a median of 82 (26-310) in primaries compared to 87 (18-404) in distant metastases. Concordance between paired tumors from the sam...    »
 
Journal title abbreviation:
Oncotarget 
Year:
2015 
Journal volume:
Journal issue:
35 
Pages contribution:
37169-84 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie