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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Olsson, Eleonor; Winter, Christof; George, Anthony; Chen, Yilun; Howlin, Jillian; Tang, Man-Hung Eric; Dahlgren, Malin; Schulz, Ralph; Grabau, Dorthe; van Westen, Danielle; Fernö, Mårten; Ingvar, Christian; Rose, Carsten; Bendahl, Pär-Ola; Rydén, Lisa; Borg, Ake; Gruvberger-Saal, Sofia K; Jernström, Helena; Saal, Lao H 
Title:
Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease. 
Abstract:
Metastatic breast cancer is usually diagnosed after becoming symptomatic, at which point it is rarely curable. Cell-free circulating tumor DNA (ctDNA) contains tumor-specific chromosomal rearrangements that may be interrogated in blood plasma. We evaluated serial monitoring of ctDNA for earlier detection of metastasis in a retrospective study of 20 patients diagnosed with primary breast cancer and long follow-up. Using an approach combining low-coverage whole-genome sequencing of primary tumors...    »
 
Journal title abbreviation:
EMBO Mol Med 
Year:
2015 
Journal volume:
Journal issue:
Pages contribution:
1034-47 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1757-4676 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie