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Document type:
Journal Article 
Author(s):
Leo, Vonny I; Tan, Sze Huey; Bergmann, Hanna; Cheah, Peh Yean; Chew, Min Hoe; Lim, Kiat Hon; Ruland, Jürgen; Reilly, Patrick T 
Title:
CARD9 Promotes Sex-Biased Colon Tumors in the APCmin Mouse Model. 
Abstract:
Caspase recuitment domain-containing protein 9 (CARD9) functions in different inflammation pathways to elicit responses to microbial signals and is known to affect intestinal inflammation. Examining the APC(min) mouse model of intestinal tumorigenesis and using stringently controlled, sex- and age-matched pairs of CARD9-competent and CARD9-deficient mice, we have found that CARD9 has a restricted but strong effect on tumorigenesis in the large intestine. We have found that CARD9 reduces viabilit...    »
 
Journal title abbreviation:
Cancer Immunol Res 
Year:
2015 
Journal volume:
Journal issue:
Pages contribution:
721-6 
Language:
eng 
Print-ISSN:
2326-6066 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie