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Document type:
Zeitschriftenaufsatz 
Author(s):
Finegold, Michael; Drton, Mathias 
Title:
Robust graphical modeling of gene networks using classical and alternative t-distributions 
Abstract:
Graphical Gaussian models have proven to be useful tools for exploring network structures based on multivariate data. Applications to studies of gene expression have generated substantial interest in these models, and resulting recent progress includes the development of fitting methodology involving penalization of the likelihood function. In this paper we advocate the use of multivariate t-distributions for more robust inference of graphs. In particular, we demonstrate that penalized likelihoo...    »
 
Keywords:
EM algorithm, graphical model, Markov chain Monte Carlo, multivariate t-distribution, penalized likelihood, robust inference 
Dewey Decimal Classification:
510 Mathematik 
Journal title:
The Annals of Applied Statistics 
Year:
2011 
Journal volume:
Year / month:
2011-07 
Quarter:
3. Quartal 
Month:
Jul 
Journal issue:
2A 
Pages contribution:
1057-1080 
Language:
en 
Fulltext / DOI:
Publisher:
Institute of Mathematical Statistics 
E-ISSN:
1932-6157 
Date of publication:
13.07.2011 
Format:
Text