User: Guest  Login
Document type:
Zeitschriftenaufsatz 
Author(s):
Erhart, Friedrich; Hackl, Matthias; Hahne, Hannes; Buchroithner, Johanna; Meng, Chen; Klingenbrunner, Simone; Reitermaier, René; Fischhuber, Katrin; Skalicky, Susanna; Berger, Walter; Spiegl-Kreinecker, Sabine; Lötsch, Daniela; Ricken, Gerda; Kuster, Bernhard; Wöhrer, Adelheid; Widhalm, Georg; Hainfellner, Johannes; Felzmann, Thomas; Dohnal, Alexander M.; Marosi, Christine; Visus, Carmen 
Title:
Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors 
Abstract:
Glioblastoma is the most prevalent and aggressive brain cancer. With a median overall survival of ~15–20 months under standard therapy, novel treatment approaches are desperately needed. A recent phase II clinical trial with a personalized immunotherapy based on tumor lysate-charged dendritic cell (DC) vaccination, however, failed to prolong survival. Here, we investigated tumor tissue from trial patients to explore glioblastoma survival-related factors. We followed an innovative approach of com...    »
 
Keywords:
Cancer therapy; Cell vaccines; CNS cancer; Translational research; Tumour immunology 
Journal title:
npj Vaccines 
Year:
2020 
Journal volume:
Journal issue:
Publisher:
Springer Science and Business Media LLC 
E-ISSN:
2059-0105 
Date of publication:
16.01.2020