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Document type:
journal article 
Author(s):
Xia, Yuchen; Schlapschy, Martin; Morath, Volker; Roeder, Natalie; Vogt, Elisabeth I; Stadler, Daniela; Cheng, Xiaoming; Dittmer, Ulf; Sutter, Kathrin; Heikenwalder, Mathias; Skerra, Arne; Protzer, Ulrike 
Title:
PASylated interferon ? efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice. 
Abstract:
Interferon ? (IFN?) so far is the only therapeutic option for chronic hepatitis B virus (HBV) infection that can lead to virus clearance. Unfortunately, its application is limited by side effects and response rates are low. The aim of this study was to generate a novel long-acting IFN? with the help of PASylation technology that adds a polypeptide comprising Proline, Alanine and Serine (PAS) to increase plasma half-life. Following evaluation of four selected recombinant murine IFN? (mIFN?) subty...    »
 
Journal title abbreviation:
Antiviral Res 
Year:
2019 
Journal volume:
161 
Pages contribution:
134-143 
Language:
eng 
Print-ISSN:
0166-3542 
TUM Institution:
Institut für Virologie