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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Clemmensen, Christoffer; Jall, Sigrid; Kleinert, Maximilian; Quarta, Carmelo; Gruber, Tim; Reber, Josefine; Sachs, Stephan; Fischer, Katrin; Feuchtinger, Annette; Karlas, Angelos; Simonds, Stephanie E; Grandl, Gerald; Loher, Daniela; Sanchez-Quant, Eva; Keipert, Susanne; Jastroch, Martin; Hofmann, Susanna M; Nascimento, Emmani B M; Schrauwen, Patrick; Ntziachristos, Vasilis; Cowley, Michael A; Finan, Brian; Müller, Timo D; Tschöp, Matthias H 
Title:
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes. 
Abstract:
Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued as a viable anti-obesity strategy. Here, we report that pharmacological activation of the cold receptor transient receptor potential cation channel subfamily M member 8 (TRPM8) with agonist icilin mimics the metabolic benefits of cold exposure. In diet-induced obese (DIO) mice, treatment with icilin enhances energy expenditure, and decreases body weight, without a...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2018 
Journal volume:
Journal issue:
Pages contribution:
4304 
Print-ISSN:
2041-1723 
TUM Institution:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos); Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)