User: Guest  Login
Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. 
Author(s):
Huang, Jianfeng; Duran, Angeles; Reina-Campos, Miguel; Valencia, Tania; Castilla, Elias A; Müller, Timo D; Tschöp, Matthias H; Moscat, Jorge; Diaz-Meco, Maria T 
Title:
Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor. 
Abstract:
Obesity is a leading risk factor for cancer. However, understanding the crosstalk between adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in the field. Here we used a prostate cancer (PCa) mouse model in which the signaling adaptor p62/Sqstm1 is selectively inactivated in adipocytes. p62 loss in adipocytes results in increased osteopontin secretion, which mediates tumor fatty acid oxidation and invasion, leading to aggressive metastatic PCa in vivo. Fur...    »
 
Journal title abbreviation:
Cancer Cell 
Year:
2018 
Journal volume:
33 
Journal issue:
Pages contribution:
770-784.e6 
Print-ISSN:
1535-6108 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)