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- Original title:
- Clearance-Mechanismen von Amyloid-β bei der Alzheimer-Krankheit
- Translated title:
- Clearance mechanisms of β-amyloid in Alzheimer’s disease
- Author:
- Goldhardt, Oliver
- Year:
- 2019
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Medizin
- Advisor:
- Grimmer, Timo (Prof. Dr.)
- Referee:
- Grimmer, Timo (Prof. Dr.); Förstl, Johann (Prof. Dr.)
- Language:
- de
- Subject group:
- MED Medizin; PSY Psychologie
- Keywords:
- Amyloid-β, Alzheimer, Neprilysin, Low-Density-Lipoprotein Receptor-related Protein 1, LRP-1, NEP
- Translated keywords:
- β-amyloid, Alzheimer, Neprilysin, Low-Density-Lipoprotein Receptor-related Protein 1, LRP-1, NEP
- TUM classification:
- MED 600d; PSY 750d
- Abstract:
- Eine gestörte Amyloid(Aβ)-Clearance wird als Ursache der sporadischen Alzheimer-Krankheit vermutet. Zwei Clearance-Mechanismen wurden an Patienten untersucht: Das T-Allel des C667T-Polymorphismus des Low-Density-Lipoprotein Receptor-related Protein 1 (LRP-1)-Transportergens korrelierte mit der zerebralen Aβ-Menge. Die anti-amyloiderge Neprilysin-Aktivität im Liquor (NEP) war positiv mit Biomarkern für neuronale Schädigung korreliert und invers mit der Aβ42-Liquorkonzentration.
- Translated abstract:
- An impaired amyloid (Aβ) clearance is a suspected cause in sporadic Alzheimer’s disease. Two mechanisms of Aβ clearance have been investigated in patients: The T allele of the C667T polymorphism of the Low-Density-Lipoprotein Receptor-related Protein 1 (LRP-1) transporter gene was positively associated with the cerebral amyloid load. The anti-amyoidogenic NEP activity in the CSF (NEP) was positively associated with biomarkers for neuronal injury and inversely with the CSF-Aβ42 concentration.
- WWW:
- https://mediatum.ub.tum.de/?id=1507336
- Date of submission:
- 01.07.2019
- Oral examination:
- 20.12.2019
- File size:
- 1142313 bytes
- Pages:
- 58
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20191220-1507336-1-2
- Last change:
- 24.01.2020
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