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Document type:
journal article 
Author(s):
Buck, Dorothea; Andlauer, Till Fm; Igl, Wilmar; Wicklein, Eva-Maria; Mühlau, Mark; Weber, Frank; Köchert, Karl; Pohl, Christoph; Arnason, Barry; Comi, Giancarlo; Cook, Stuart; Filippi, Massimo; Hartung, Hans-Peter; Jeffery, Douglas; Kappos, Ludwig; Barkhof, Frederik; Edan, Gilles; Freedman, Mark S; Montalbán, Xavier; Müller-Myhsok, Bertram; Hemmer, Bernhard; BEYOND and BENEFIT Study Groups 
Title:
Effect of HLA-DRB1 alleles and genetic variants on the development of neutralizing antibodies to interferon beta in the BEYOND and BENEFIT trials. 
Abstract:
Treatment of multiple sclerosis (MS) with interferon ? can lead to the development of antibodies directed against interferon ? that interfere with treatment efficacy. Several observational studies have proposed different HLA alleles and genetic variants associated with the development of antibodies against interferon ?.To validate the proposed genetic markers and to identify new markers.Associations of genetic candidate markers with antibody presence and development were examined in a post hoc a...    »
 
Journal title abbreviation:
Mult Scler 
Year:
2019 
Journal volume:
25 
Journal issue:
Pages contribution:
565-573 
Language:
eng 
Print-ISSN:
1352-4585 
TUM Institution:
Klinik und Poliklinik für Neurologie