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Document type:
journal article 
Author(s):
Scheltens, Philip; Hallikainen, Merja; Grimmer, Timo; Duning, Thomas; Gouw, Alida A; Teunissen, Charlotte E; Wink, Alle Meije; Maruff, Paul; Harrison, John; van Baal, Caroline M; Bruins, Suzanne; Lues, Inge; Prins, Niels D 
Title:
Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study. 
Abstract:
PQ912 is an inhibitor of the glutaminyl cyclase enzyme that plays a central role in the formation of synaptotoxic pyroglutamate-A-beta oligomers. We report on the first clinical study with PQ912 in subjects with biomarker-proven Alzheimer's disease (AD). The aim was to determine the maximal tolerated dose, target occupancy and treatment-related pharmacodynamic effects. The exploratory efficacy readouts selected were tailored to the patient population with early AD. The therapeutic approach focus...    »
 
Journal title abbreviation:
Alzheimers Res Ther 
Year:
2018 
Journal volume:
10 
Journal issue:
Pages contribution:
107 
Language:
eng 
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie