XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.

Dokumenttyp:: Letter
Autor(en):: Müller, Nicole; Fischer, Julius C; Yabal, Monica; Haas, Tobias; Poeck, Hendrik; Jost, Philipp J
Titel:: XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.
Abstract:: Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent.
Zeitschriftentitel:: Eur J Immunol
Jahr:: 2019
Band / Volume:: 49
Heft / Issue:: 3
Seitenangaben Beitrag:: 504-507
Sprache:: eng
Volltext / DOI:: doi:10.1002/eji.201847818
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/30585320
Print-ISSN:: 0014-2980
TUM Einrichtung:: III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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