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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Fornasiero, Eugenio F; Mandad, Sunit; Wildhagen, Hanna; Alevra, Mihai; Rammner, Burkhard; Keihani, Sarva; Opazo, Felipe; Urban, Inga; Ischebeck, Till; Sakib, M Sadman; Fard, Maryam K; Kirli, Koray; Centeno, Tonatiuh Pena; Vidal, Ramon O; Rahman, Raza-Ur; Benito, Eva; Fischer, Andre; Dennerlein, Sven; Rehling, Peter; Feussner, Ivo; Bonn, Stefan; Simons, Mikael; Urlaub, Henning; Rizzoli, Silvio O 
Title:
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions. 
Abstract:
The turnover of brain proteins is critical for organism survival, and its perturbations are linked to pathology. Nevertheless, protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically labeled amino acids, followed by mass spectrometry analyses. In vivo proteins are generated from at least two sources: labeled amino acids from the diet, and non-labeled amino acids from the degradation of pre-existing proteins. This renders meas...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2018 
Journal volume:
Journal issue:
Print-ISSN:
2041-1723 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)